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Paeonia Albiflora Root(Peony) Extract's Clinical use

Source:http://www.webmd.com/      Date:Sep 12, 2016

Peony Root Extract

History

Peony root is a major Chinese medicinal herb that has been used for thousands of years. Peony root was described in the Materia Medica of Traditional Chinese Medicine during the Han Dynasty (206 BC to 220 AD). Peony is also listed in over 30 formulas in a classic text of early Chinese medicine, the Shang Han Lun (Discussion of Cold-Induced Disorders), and is also listed in the pharmacopoeias of China and Japan. It is one of the commonly used ingredients in liver disease treatment. The primary active components of peony root are alkaloids, glucosides, polysaccharides, saponins, organic acids and trace minerals.

Total Glucosides of Peony (TGP)/Paeoniflorin

In the mid-1980s researchers developed a process to extract a standardized compound containing a mini-mum of 40 percent paeoniflorin, the principal active ingredient in peony. This standardized extract, called Total Glucosides of Peony (TGP), has been the subject of extensive research in China for over 20 years. A number of clinical studies have found that TGP possesses both anti-inflammatory and immune modulation effects.

Generally,The appearance is standard extract powder,Paeoniflorin8%-95%.

Peony is a plant. The root and, less commonly, the flower and seed are used to make medicine.

Uses below:

Skin wrinkles. Peony contains a chemical called paeoniflorin. Early research suggests that applying a specific cosmetic product containing 0.5% paeoniflorin for 8 weeks might reduce facial wrinkles.

Muscle cramps.Early research suggests that taking a specific combination of peony and licorice (Shakuyaku-kanzoh-to) might ease muscle cramps in people with liver cirrhosis and in people undergoing hemodialysis.

Rheumatoid arthritis (RA). Early research suggests that taking a product containing peony along with the drug methotrexate for 3 months might reduce test markers of swelling in people with RA better than taking methotrexate alone. However, taking this peony product with methotrexate does not appear to improve symptoms of RA better than methotrexate alone.

Gout.

Osteoarthritis.

Breathing problems.

Cough.

Skin diseases.

Hemorrhoids.

Heart trouble.

Stomach upset.

Spasms.

Nerve problems.

Migraine headache.

Chronic fatigue syndrome (CFS).

Other conditions.

More evidence is needed to rate the effectiveness of peony for these uses.

Peony is POSSIBLY SAFE when used by mouth, short-term. Peony has been used safely for up to 4 weeks. It can cause stomach upset. It can cause rash when it comes in contact with the skin of sensitive people.

Human Clinical Trials

Human clinical trials in China support the therapeutic benefits of peony extract for rheumatoid arthritis. In one study, 120 patients with rheumatoid arthritis received either a standardized peony extract (TGP) or methotrexate (MTX) an established treatment for RA that was used as a control. After four weeks of treatment, both TGP and MTX were found to be equally effective.

These results were replicated in a second study involving 263 Rheumatoid arthritis patients given doses of standardized TGP peony extract. In this study 142 patients again were given MTX to serve as controls. After four weeks, 77 percent of patients receiving the peony extract reported improvement of symptoms – a figure again matched by the methotrexate control group. One difference that did surface in this second study was that peony extract had a normalizing effect on immune function. Additionally, patients receiving the peony extract reported noticeable improvements in both the quality of life and increases in physical strength. These improvements were not reported by patients receiving MTX.

Special Precautions & Warnings:

Pregnancy and breast-feeding: Peony is POSSIBLY UNSAFE when taken by mouth during pregnancy. Some developing research suggests that peony can cause uterine contractions. However, other research suggests a combination of peony and angelica might be safe. Until more is known, don’t use peony if you are pregnant. Also avoid peony if you are breast-feeding. Not enough is known about the safety of using peony if you are nursing.

Bleeding disorders: Because peony might slow blood clotting, there is a concern that it might increase the risk of bleeding in people with bleeding disorders. Don’t use it if you have a bleeding disorder.

Surgery: Peony might slow blood clotting, so there is a concern that it could increase the chance of bleeding during and after surgery. Stop using peony at least 2 weeks before a scheduled surgery.

Interactions

Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs) interacts with PEONY

Peony might slow blood clotting. Taking peony along with medications that also slow clotting might increase the chances of bruising and bleeding.

Some medications that slow blood clotting include aspirin, clopidogrel (Plavix), diclofenac (Voltaren, Cataflam, others), ibuprofen (Advil, Motrin, others), naproxen (Anaprox, Naprosyn, others), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, warfarin (Coumadin), and others.

Phenytoin (Dilantin) interacts with PEONY

Peony root might decrease the amount of phenytoin in the body. Taking peony root along with phenytoin (Dilantin) might decrease the effectiveness of phenytoin (Dilantin) and increase the risk of seizures.

Peony Dosing

The appropriate dose of peony depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for peony. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.


References:http://www.webmd.com/vitamins-supplements/ingredientmono-32-PEONY.aspx?activeIngredientId=32&activeIngredientName=PEONY

http://nutritionreview.org/2013/04/unique-chinese-extract-relieves-symptoms-rheumatoid-arthritis/



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